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Day 28 31) effects on neuronal responses and pain behaviour were determined. Intra articular injection of 1mg MIA produced stable and robust changes in two measures of pain relevant to clinical OA, and evidence for the presence of central sensitisation was demonstrated. It was also demonstrated that early stage painful responses in this model are not associated with changes in cytokines in the joint.Effects of spinal and systemic administration of nimesulide (3 100IJg in 501JL)on mechanically evoked and post stimulus responses of dorsal horn neurones in MIA treated rats were also measured, as were the effects of spinal cannabinoid receptor antagonism with AM251 (0.1 10IJg in 501JL)and the CB2 receptor antagonist SR144528 (0.001 0.1IJg in 50IJL).

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anabolic steroids Any statements in this release that are not historical facts may be considered such “forward looking statements.” Forward looking statements are based on management’s current expectations and are subject to risks and uncertainties which may cause results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include risks and uncertainties related to Imprimis’ ability to make commercially available its compounded formulations and technologies in a timely manner or at all; physician interest in prescribing its formulations; risks related to its compounding pharmacy operations; its ability to enter into other strategic alliances, including arrangements with pharmacies, physicians and healthcare organizations for the development and distribution of its formulations; its ability to obtain intellectual property protection for its assets; its ability to accurately estimate its expenses and cash burn, and raise additional funds when necessary; risks related to research and development activities; the projected size of the potential market for its technologies and formulations; unexpected new data, safety and technical issues; regulatory and market developments impacting compounding pharmacies, outsourcing facilities and the pharmaceutical industry; competition; and market conditions. These and additional risks and uncertainties are more fully described in Imprimis’ filings with the Securities and Exchange Commission, including its Annual Report on Form 10 K and its Quarterly Reports on Form 10 Q anabolic steroids.